Effects 16 new biomarker genes were being identified on gene expression Evaluation by cDNA microarray. MDR1 gene was selected as one of the most powerful goal gene and silencing of it caused down-regulation of MDR1 , ALDH1A3 , EGFR , BAG4 expression and P-glycoprotein exercise and expression in BCSC-like cells. At the tip, silenced BCSC-like cells